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8 Best Supplements for Anxiety, According to Registered Dietitians

These research-backed supplements may help combat anxiety and depression.

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supplements for anxiety

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Roughly 31% of adult Americans experience an anxiety disorder at some point in their lives. Severe anxiety disorders can even interfere with daily activities such as your performance at work, school and personal relationships.

While a healthy diet isn't an anxiety cure-all, balanced eating habits, exercise, sleep and other lifestyle practices may be the first step in managing anxiety symptoms. Certain nutrients may play a role in reducing anxiety as well. While supplements are not a substitute for anxiety treatment or a healthy lifestyle, there are some options that may help manage anxiety when complemented with appropriate lifestyle habits and therapy.

"There’s evidence that certain supplements might reduce symptoms. But they aren’t a substitute for other behaviors, like a nutritious diet, exercise, stress management tools, therapy and medication, if needed," says New York City-based registered dietitian Samantha Cassetty, M.S., R.D., nutrition and wellness expert and co-author of Sugar Shock. "You’ll get the most benefit from a supplement if you combine it with other measures."

If deemed appropriate by your healthcare provider, a supplement for anxiety may be beneficial in helping manage some anxiety symptoms. But given that supplements are not approved by the U.S. Food and Drug Administration (FDA) prior to going to market, it's extra important to do your research to make sure that what is on the label is actually in the bottle.

You can learn more about how the Good Housekeeping Institute Nutrition Lab evaluates supplements, including tips for finding the best supplement for anxiety that will work for you, at the end of this guide. If you're looking for more tips on naturally alleviating anxiety, check out some other expert-approved ways to stop feeling anxious.

Take note: Our nutrition pros stress that a supplement should do just that: supplement the diet, not replace high-quality, healthy food. Check with your healthcare provider before starting any dietary supplement regimen.

1
Best Magnesium

Nature Made Magnesium Glycinate, 200 mg

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Magnesium Glycinate, 200 mg
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Credit: Nature Made

Pros

  • Form is more absorbable yet gentle on the stomach
  • Free from artificial flavors and added colors

Cons

  • Two large capsules per serving

"Magnesium is involved in your stress response and mood regulation, and most Americans don’t get enough magnesium in their diet," Cassetty says.

There are many types of magnesium available, but magnesium glycinate is a highly absorbable form that has shown some promise in alleviating anxiety and stress. This magnesium glycinate supplement from Nature Made is formulated for optimal absorption but to also be gentle on the stomach. (Take note that in general, large doses of magnesium can have a laxative effect.) The softgels are somewhat large and require two capsules per serving, but they are free from artificial flavors and added colors. Nature Made products are manufactured to meet very high quality standards, and many of their supplements (including their magnesium citrate) are United States Pharmacopeia (USP) Verified.

"Research suggests that the combination of magnesium with vitamin B6 or zinc may help improve symptoms in people with mild anxiety," Cassetty explains. She adds that although some of the research on magnesium and anxiety doesn’t show a benefit, magnesium is still an essential mineral, so it’s helpful to get enough through diet or a combination of diet and supplementation.

2
Best Omega 3s

Nordic Naturals Ultimate Omega, 1280 mg

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Ultimate Omega, 1280 mg
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Credit: Nordic Naturals

Pros

  • No smell or fishy aftertaste
  • Third-party tested with COA available for every product

Cons

  • Pills are quite large

"There’s evidence that omega-3 fish oils may help relieve anxiety symptoms," Cassetty says. "Omega 3s may interfere with the biological mechanisms, such as inflammation, that promote anxiety, which is why they could help alleviate symptoms."

Our top omega-3 supplement pick is from Nordic Naturals, a leading fish oil brand that offers a variety of forms and dosages of high-quality fish oil. You'll find a total of 1,280 mg omega-3s per two-softgel serving, which is best taken with food.

Free from artificial colors and flavors, this supplement is naturally flavored with lemon to offset any fishy aftertaste. While the pills are a bit large, we found that they do not smell and reviewers say that they do not make them burp. We appreciate that all Nordic Naturals products are non-GMO and third-party tested. The brand openly shares Certificates of Analyses for all of its products, and you can easily scan the QR code on the packaging of your product to see the test results yourself.

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3
Best Ashwagandha

GNC Herbal Plus Ashwagandha Extract, 470mg

Herbal Plus Ashwagandha Extract, 470mg
Credit: GNC

Pros

  • Only one capsule per serving
  • Passed tests with ConsumerLab.com

Cons

  • May cause mild drowsiness and GI discomfort

Ashwagandha is a type of Ayurvedic herb that research suggests may play a role in reducing symptoms of anxiety and stress, which is why you'll typically see it in a variety of stress management supplements.

It comes in several forms including pills, powders and capsules. Some potential side effects of taking Ashwagandha generally include mild drowsiness and some GI discomfort. Ashwagandha, like many herbal supplements, are not recommended for pregnant women. That being said, it is usually well tolerated by most populations.

This high-quality Ashwagandha from GNC contains 470 mg of the root extract and only requires one capsule per serving. Plus, this choice is approved by ConsumerLab.com through their voluntary Quality Certification Program, which confirmed that the supplement contains 7.2 mg withanolides, compounds that give Ashwaghanda its stress-relieving properties.

4
Best L-Theanine

NOW L-Theanine 200 mg, Stress Management

L-Theanine 200 mg, Stress Management
Credit: Now

Pros

  • Combination of L-theanine and inositol
  • Tested for potency and purity

Cons

  • L-theanine may cause headaches in some people

"L-theanine is a relaxation-promoting compound found in green tea," Cassetty explains. "Supplementing with L-theanine for four weeks has been found to promote better sleep and lower stress-related symptoms among healthy people. It’s also been found to reduce stress and anxiety symptoms among people exposed to a stressful situation."

But Cassetty does note that while the research on L-theanine is promising, we need better long-term evidence to say whether this would be a helpful supplement over time.

This L-Theanine supplement from Now is curated specifically for stress management and includes 200 mg of L-Theanine complemented by 100 mg inositol, a type of sugar made in the body and found in foods that may help balance certain chemicals in the body for conditions such as panic attacks and depression.

Just keep in mind that L-theanine may cause headaches in some people, so be sure to discuss this supplement and any new supplement you are adding to your regimen with your doctor. Now has strict in-house quality processes and third-party accredited labs to ensure potency and purity in their products.

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5
Best Vitamin D

Kirkland Signature Extra Strength Vitamin D3 2000 I.U.

Extra Strength Vitamin D3 2000 I.U.
Now 30% Off
Credit: Kirkland Signature

Pros

  • Affordable and high-quality
  • USP Verified
  • Only one softgel per serving

Cons

  • Large container may be difficult to store

The sunshine vitamin plays a big role in your overall health, including your mental health. "Low vitamin D status is linked to higher odds of anxiety, and the latest data suggest that about 65% of people have insufficient levels. Since vitamin D insufficiency is so common and is involved in so many other areas of health, many people could potentially benefit from supplementing," Cassetty says. "There’s some evidence that correcting vitamin-D levels can help improve anxiety symptoms after supplementing for six months." She adds that there are several ways that vitamin D may be a factor in anxiety, such as its role in taming inflammation and oxidative stress.

Not only is this vitamin D supplement from Costco's Kirkland Signature brand affordable, but it's also very high quality. Each softgel contains 2,000 IU of D3 and is USP-verified, meaning it has passed rigorous testing to ensure the quality and purity of the product. You won't have to worry about rushing to the store for a refill any time soon either since there are 600 servings in each container. However, the container is large, so storing it may be more difficult.

6
Best GABA

Solgar GABA 500 mg

Amazon’s Choice
GABA 500 mg
Credit: Solgar

Pros

  • Passed tests with ConsumerLab.com
  • Also certified gluten-free

Cons

  • Mixed findings on GABA's relationship with the blood-brain barrier

Gamma-aminobutyric acid (a.k.a. GABA) is a type of neurotransmitter, which is a chemical messenger in the brain. It works to block certain signals in your central nervous system to actually slow down the brain, and is thought to play a role in controlling specific cell activity that is associated anxiety and stress. "Increased GABA provides a protective and calming effect on the brain and body," Cassetty explains. "Magnesium also helps regulate GABA, the neurotransmitter that promotes relaxation and sleep." However, more research is needed on GABA supplementation and its efficacy, as there are mixed findings on its relationship with the blood-brain barrier.

This vegan GABA supplement from Solgar contains 500 mg of GABA and can be taken up to two times a day between meals. It's also certified gluten-free and approved by ConsumerLab.com through their voluntary Quality Certification Program, which confirmed that the supplement does contain the claimed 500 mg GABA.

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7
Best Probiotic

Garden of Life Once Daily Dr. Formulated Probiotics for Women

On Sale
Once Daily Dr. Formulated Probiotics for Women

Pros

  • Passed tests with ConsumerLab.com
  • Also NSF Contents Certified
  • No refrigeration required

Cons

  • Not specifically formulated for anxiety

"It is well studied that foods we eat can have a positive or negative influence on gut bacteria and therefore anxiety as well," says licensed naturopathic physician and registered dietitian Jaime Schehr, N.D., R.D., C.D.N., who is the assistant director of academic integrative family medicine at the Institute for Family Health of Mt. Sinai. "The microbiome (gut bacteria) are largely influenced by nutrition through the ability of food to either promote healthy bacteria growth or support unwanted bacterial overgrowth." Since there is a relationship with the brain and gut, it is possible that anxiety and even depression may trigger gastrointestinal symptoms and vice versa. There are mixed results on probiotics and anxiety in regards to the current research, but certain conditions like chronic abdominal pain or diarrhea may result in anxiety or depression. A probiotic can potentially help manage those digestive symptoms.

Developed by a board-certified neurologist, our top probiotic pick is this supplement from Garden of Life that is packed with 16 probiotic strains and 50 billion Colony Forming Units (CFU). This probiotic in particular is gluten-free, dairy-free, soy-free, vegetarian and Non-GMO Project Verified. It's not specifically formulated for anxiety, but ConsumerLab.com confirmed 50 billion CFU at expiration date under the recommended storage conditions through their voluntary Quality Certification Program. Unlike other probiotics, this one does not need to be refrigerated, plus it's NSF Certified Gluten-Free and NSF Contents Certified too.

8
Best Stress Management Complex

Pure Encapsulations Daily Stress Formula

Daily Stress Formula
Credit: Pure Encapsulations

Pros

  • Contains a blend of several key vitamins and functional ingredients
  • Passed tests with ConsumerLab.com

Cons

  • Three capsules per serving

If you're looking for a comprehensive stress management supplement that has a little bit of everything, this complex supplement from Pure Encapsulations may be the right choice for you. It contains several B vitamins, vitamin C and magnesium, but also includes a few extra ingredients targeted to managing stress and anxiety including Ashwagandha, chamomile, L-Tyrosine and more.

The pills are a standard size, but a serving is three capsules. That being said, this supplement is certified gluten-free and also naturally vegan. This pick is also approved by ConsumerLab.com through their voluntary Quality Certification Program.

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How we choose the best supplements for anxiety

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Year-round, the Good Housekeeping Institute Nutrition Lab rigorously evaluates all different types of supplements, from B12 supplements to iron supplements, based on nutritional expertise, ingredients and third-party testing data. For this story, we researched supplements and nutrients that have been shown to help with symptoms of anxiety and stress. We then looked for top-quality choices in each category, largely based on prior category testing including our best vitamin D supplements and our best magnesium supplements.

analyzing supplements in the good housekeeping institute nutrition lab
Philip Friedman

Our registered dietitians considered form, type, dosage, serving size, price, servings per container, ingredients and whether or not you can take the supplement with or without food. When making our final selections, we aimed to provide options for a variety of personal preferences and price points.

We prioritized recommendations that have been tested for purity, potency and safety by a credible third-party organization, as well as products with strict internal quality control standards. We specifically looked at ingredient lists and product quality.

Since the U.S. Food and Drug Administration (FDA) does not approve dietary supplements for safety and effectiveness prior to going to market, it's incredibly important to thoroughly research each supplement you add to your regimen and speak with your doctor before purchasing.

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What to look for when shopping for a supplement for anxiety

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Since there isn't necessarily one vitamin or nutrient that is best for anxiety, it's important to speak with your healthcare provider to determine the appropriate type of supplement to meet your needs. They may even request to draw bloodwork to see if any potential underlying nutrient deficiencies are playing a role in your anxiety and symptoms. There are some other considerations to keep in mind when finding an anxiety supplement that is best for you.

✔️ Pill type: Supplements come in capsules, chewables, gummies, lozenges and more. Most of the supplements on this list are a capsule or softgel, but many of the brands do offer gummy alternatives which may be easier for you to take.

✔️ Size: Check the serving size and consider the size of the pill itself. Would you rather take one pill daily, or are you OK with a few pills to meet the recommended serving size. Regardless, speak with your healthcare provider to find the appropriate dose for your needs.

✔️ Price: Supplements can vary greatly in price, and more expensive options aren't necessarily better. Plus, each bottle contains a different number of pills and serving size can vary, so we included information on cost per dosage so you can accurately compare each option. Keep in mind that some supplements also include other nutrients, like a larger complex with multiple ingredients, which may be more expensive than a single-ingredient supplement.

✔️ Interactions: Always be sure to speak with your healthcare provider to determine whether or not the supplement you choose will interact with any of your current existing medications or conditions.

What is anxiety?

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According to the American Psychiatric Association, anxiety refers to anticipation of a future concern and is more associated with muscle tension and avoidance behavior, whereas fear is an emotional response to an immediate threat and is more associated with a fight or flight reaction. There are also several types of anxiety disorders which include generalized anxiety disorder, panic disorder with or without agoraphobia, specific phobias, agoraphobia, social anxiety disorder, separation anxiety disorder and selective mutism.

"Oftentimes people confuse anxiety and stress — they are both emotional responses," says licensed psychologist, speaker and consultant Rachel L. Goldman, Ph.D., FTOS, who takes a holistic approach to health. "They are similar and can lead to the same symptoms, but are different. Anxiety is defined as persistent, excessive worries that don't go away in the absence of a stressor."

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What role does nutrition play in anxiety?

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"A growing body of evidence links a diet high in added sugars and refined grains with a higher risk of anxiety," Cassetty says. "In contrast, healthy dietary patterns, including the Mediterranean diet, are associated with a lower risk of anxiety." She explains that a nutrient-rich dietary pattern is high in fruits, veggies, whole grains, nuts and seeds, pulses (legumes like chickpeas, lentils, dry peas and beans) and fatty fish while low in added sugars and refined grains. "This diet supplies a spectrum of nutrients associated with protection against anxiety."

Can supplements help with anxiety?

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While supplements should never be used in place of medicine without the supervision of a medical provider, Dr. Schehr says that there are a number of OTC supplements that have mechanisms similar to medications used to treat anxiety disorders and can be effective in managing anxiety. "Supplements do not have the same rigor of study/evidence that is required of medications nor do they have the same regulatory practices around manufacture, which makes it more challenging to safely choose the right supplement for anxiety," she explains. "This is another reason why when considering supplements it should only be done in collaboration with your medical provider."

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Who may not benefit from supplements for anxiety?

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Many people can benefit from supplements, but they may not work the same for everyone, Dr. Schehr says. "Changes aren’t immediate and some supplements may have dangerous interactions with other medications so it's important that persons taking medications be more mindful."

"If you take a medication to treat a chronic condition, whether that’s a mental health condition or a physical condition such as heart disease, GI disease, or type 2 diabetes, talk to your healthcare provider before starting a supplement," Cassetty adds. "People who are pregnant or breastfeeding shouldn’t take supplements unless they discuss them with their doctor."

Both Dr. Schehr and Cassetty agree that persons with severe anxiety disorders should not rely on supplements alone to manage their anxiety. If your anxiety symptoms are new or severe, it's important to speak with your doctor before trying a supplement.

How can you manage anxiety naturally?

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"The key is to think about what works for you and what you actually see yourself doing in these situations," Dr. Goldman explains. "For some people, taking a moment to slow down is helpful in managing their anxiety, such as with a breathing exercise, meditation, mindfulness or yoga. For other people, doing something more active can be helpful, such as walking, running or high-intensity exercises." She also says that other great tools for coping with anxiety include journaling, reading, something to distract your mind, reaching out for support or talking to a friend."

Looking to calm your anxiety quickly? Dr. Goldman shares her go-to tip is diaphragmatic breathing as it immediately slows down our breathing and decreases our heart rate. "Other great in-the-moment tricks are counting, splashing your face with cold water or saying a word or words (like a mantra or self talk)."

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When should someone seek a doctor's help for anxiety symptoms?

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"If someone is asking themselves if they should see a professional for help with their symptoms, then it definitely can't hurt to reach out to someone," Dr. Goldman says. She adds that other times to consider seeing a doctor would be if your symptoms are impacting your daily functioning or if you find yourself worrying more days than not and feel like it is too challenging on your own to control. "I find that for some people with anxiety, they may need a low dose of medication to take the edge off which will then allow them to do some of the other work, like cognitive behavioral therapy and working on challenging their unhelpful thoughts."

Why trust Good Housekeeping?

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As director of the Good Housekeeping Institute Nutrition Lab, Registered Dietitian Stefani Sassos handles all nutrition-related content, product testing and evaluation. She stays up-to-date on the latest research to provide evidence-based reporting on all things diet and nutrition. Stefani runs and oversees supplement testing and analysis for Good Housekeeping and has covered several other supplements in the past including multivitamins, vegan protein powders, vitamin D and joint supplements.

Samantha Cassetty, M.S., R.D. is a nationally recognized food and nutrition expert, media personality, nutrition consultant, author and regular columnist for TODAY.com. Samantha previously served as the nutrition director for Good Housekeeping and nutrition correspondent for Drop 5 Lbs with Good Housekeeping on the Cooking Channel. She’s the co-author of Sugar Shock and a contributor to the New York Times best seller, 7 Years Younger, and the follow-up, 7 Years Younger: The Anti-Aging Breakthrough Diet.

Rachel L. Goldman, Ph.D., FTOS (a.k.a. Dr. Rachel) is a licensed psychologist, speaker and consultant who takes a holistic approach to health. She specializes in the mind-body connection, including stress reduction, disordered eating behaviors, and health behavior change. She is also Clinical Assistant Professor in the Department of Psychiatry at NYU Grossman School of Medicine and has a private practice in NYC, where she utilizes cognitive behavioral therapy to assist in behavioral. She was a consultant for the film, The Whale.

Jaime Schehr, N.D., R.D,. C.D.N., is a licensed Naturopathic physician and a Registered Dietitian practicing since 2006. Dr. Schehr is the owner of Schehr Nutrition as well as co-founder of xFitLab, a medical fitness consulting company. Dr. Schehr is the assistant director of academic integrative family medicine at the Institute for Family Health of Mt. Sinai. She is a prominent speaker in Integrative Medicine and Nutrition and is often sought to lecture in both the corporate and academic space.

Headshot of Stefani Sassos, M.S., R.D.N., NASM-CPT
Stefani Sassos, M.S., R.D.N., NASM-CPT
Nutrition & Fitness Lab Director

Stefani (she/her) is a registered dietitian, a NASM-certified personal trainer and the director of the Good Housekeeping Institute Nutrition and Fitness Lab, where she oversees all nutrition and fitness-related content, testing and evaluation. She holds a master’s degree in clinical nutrition from New York University, as well as advanced certifications as a Women's Fitness Specialist and a Behavior Change Specialist. Stefani is dedicated to providing readers with evidence-based content to encourage informed food choices and healthy living. She is an avid CrossFitter and a passionate home cook who loves spending time with her big fit Greek family.

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