11 Best Creams for Sciatica Pain
Get relief from that awful pain that hits your back and then radiates down your legs.

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If you’re among the almost 40% of the population who have sciatica, you know how tough it can be. Even the smallest twist or bend can send pain shooting from your back down to your legs. In severe cases, sciatica can be debilitating — we’re talking a can’t-even-get-out-of-bed level of pain.
The location of sciatica pain can be especially challenging, since it affects the areas of your body that facilitate lots of movement. “Sciatica pain is commonly in your buttocks, back of your thigh,and into the back or side of your calf,” says Benjamin Moor, MD, an anesthesiologist and pain specialist at Tufts Medical Center in Boston Moor. “Sometimes it can be felt throughout the foot and into the toes. It can be aching, sometimes sharp, and is often accompanied by tingling or numbness. You’ll feel the pain away from the site of the injury, say, in your foot, but the problem is in your back. Your foot is fine!” This is because sciatica pain doesn’t come from an injury to the sciatic nerve itself. The pain originates from nerves higher up in your spine, which join the sciatica nerve, and radiates downward.
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You’re most likely to get sciatica between the ages of 30 and 50. Pregnant women are especially susceptible because a growing fetus can put pressure on the sciatic nerve. And the condition tends to come and go. “Patients often talk about their sciatica ‘flaring up’,” says Dr. Moor. “As we get older, the channels where the nerves come out from our backs get tighter. This can cause pressure on a nerve root whereas, in the past, there would have been enough space for the nerve not to get squeezed. It’s the squeezing or pinching of the nerve that causes sciatica pain.” Aging can also cause spine changes like bone spurs, which could lead to flare-ups.
Treatments for sciatica can start with simple self-care, like alternating cold packs and warm compresses to gentle stretching. If you still have pain, it's important to see a physician. Prescription meds and/or physical therapy can be helpful. For severe cases of sciatica, surgery may be recommended – you can also ask your doctor about steroid injections, which a new study finds can be even more effective.
Another treatment option that can be used in conjunction with, or in place of, other treatments: over-the-counter sciatica creams. “Topical medications tend to be very safe,” says Dr. Moor. “It’s very rare to get systemic side effects from topicals. Many of the oral medications I prescribe can cause drowsiness or gastric upset in patients, but we hardly ever see those problems with medication applied to the skin. We do occasionally see rashes or redness, but usually this goes away quickly if you hold off on the medication for a few days.”
For best results, it’s important to understand how OTC sciatica creams work. “There are various ingredients to look out for when looking at over-the-counter topical medications,” says Dr. Moor.
Some effective ingredients that may be effective in OTC sciatica creams in addition to capsaicin and menthol include:
- Methylsulfonylmethane (MSM) fights inflammation
- Strychnos can help restore muscle mass and can reduce stress at the site of an injury
- Histamine dihydrochloride can regulate neuropathic pain, like compression of sciatica nerves
- Lidocaine can numb sciatic pain
- Borwella serrata can help recovery of sciatic nerve function
- Vitamin B6 can help build new nerve structures
- Arnica has been reported to reduce pain relief from injuries
- Ilex leaf extract can reduce neuropathic pain
“Many of these medications ‘confuse’ the body’s transmission of pain signals by overlying the pain stimulus with a non-painful one. Think of hitting your thumb with a hammer, then rubbing or squeezing it. Capsaicin and menthol probably work in large part by this mechanism. They cause a mild irritation, a heating or a cooling sensation of the skin, which suppresses some of the pain signals at the level of the spinal cord, stopping them reaching the brain.”
Below, you'll find the best creams for sciatica pain recommended by experts and reviewers. Further down on the page, we're also answering top questions about sciatica pain. Again, any moderate or severe pain should be discussed with a physician.

Lisa is an internationally established health writer whose credits include Good Housekeeping, Prevention, Men’s Health, Oprah Daily, Woman’s Day, Elle, Cosmopolitan, Harper’s Bazaar, Esquire, Glamour, The Washington Post, WebMD, Medscape, The Los Angeles Times, Parade, Health, Self, Family Circle and Seventeen. She is the author of eight best-selling books, including The Essentials of Theater.


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